One-Step Thermophoretic AND Gate Operation on Extracellular Vesicles Improves Diagnosis of Prostate Cancer,Angewandte Chemie International Edition

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One-Step Thermophoretic AND Gate Operation on Extracellular Vesicles Improves Diagnosis of Prostate Cancer
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-06-24 , DOI: 10.1002/anie.202207037
Jinqi Deng _{1,

2} , Shuai Zhao _{1,

2} , Junhong Li _{3,

4} , Yangchang Cheng _{1,

2} , Chao Liu _{1,

2} , Zheng Liu _{3,

4} , Lele Li _{1,

2} , Fei Tian _{1,

2} , Bo Dai _{3,

4} , Jiashu Sun _{1,

2}

Affiliation

Circulating extracellular vesicles (EVs) are emerging biomarkers for prostate cancer (PCa). A one-step thermophoretic AND gate operation (Tango) assay for accurate identification of PCa-derived EVs directly in serum samples within 15 min is reported. The assay reached an overall accuracy of 91 % in discriminating PCa from benign prostatic hyperplasia (BPH) in a single-step format, showing great potential for rapid, non-invasive diagnosis of cancers.

中文翻译：

细胞外囊泡的一步热泳和门操作提高前列腺癌的诊断

循环细胞外囊泡 (EV) 是前列腺癌 (PCa) 的新兴生物标志物。报告了一种一步热泳与门操作 (Tango) 测定法，可在 15 分钟内直接在血清样本中准确鉴定 PCa 衍生的 EV。该测定在以单步形式区分 PCa 和良性前列腺增生 (BPH) 方面的总体准确率达到 91%，显示出快速、非侵入性诊断癌症的巨大潜力。

更新日期：2022-06-24

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