pH-Activatable Organic Nanoparticles for Efficient Low-Temperature Photothermal Therapy of Ocular Bacterial Infection,ACS Nano

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pH-Activatable Organic Nanoparticles for Efficient Low-Temperature Photothermal Therapy of Ocular Bacterial Infection
ACS Nano ( IF 15.8 ) Pub Date : 2022-06-24 , DOI: 10.1021/acsnano.2c03971
Kangning Zhu _{1,

2} , Siyuan Qian ₁ , Hanwen Guo ₁ , Qingying Wang ₁ , Xiaoying Chu ₁ , Xinyi Wang ₁ , Si Lu ₁ , Yaou Peng ₁ , Yishun Guo ₁ , Zhongqiang Zhu ₁ , Tianyi Qin ₃ , Bin Liu ₄ , Ying-Wei Yang ₅ , Bailiang Wang _{1,

2}

Affiliation

Low-temperature photothermal therapy (PTT) systems constructed by integrating organic photothermal agents with other bactericidal components that initiate bacterial apoptosis at low hyperthermia possess a promising prospect. However, these multicomponent low-temperature PTT nanoplatforms have drawbacks in terms of the tedious construction process, suboptimal synergy effect of diverse antibacterial therapies, and high laser dose needed, compromising their biosafety in ocular bacterial infection treatment. Herein, a mild PTT nanotherapeutic platform is formulated via the self-assembly of a pH-responsive phenothiazinium dye. These organic nanoparticles with photothermal conversion efficiency up to 84.5% necessitate only an ultralow light dose of 36 J/cm² to achieve efficient low-temperature photothermal bacterial inhibition at pH 5.5 under 650 nm laser irradiation. In addition, this intelligent mild photothermal nanoplatform undergoes negative to positive charge reversion in acid biofilms, exhibiting good penetration and highly efficient elimination of drug-resistant E. coli biofilms under photoirradiation. Further in vivo animal tests demonstrated efficient bacterial elimination and inflammatory mitigation as well as superior biocompatibility and biosafety of the photothermal nanoparticles in ocular bacterial infection treatment. Overall, this efficient single-component mild PTT system featuring simple construction processes holds great potential for wide application and clinical transformation.

中文翻译：

用于眼部细菌感染的高效低温光热治疗的 pH 可激活有机纳米颗粒

通过将有机光热剂与其他杀菌成分结合构建的低温光热疗法 (PTT) 系统在低温下启动细菌凋亡具有广阔的前景。然而，这些多组分低温PTT纳米平台在繁琐的构建过程、多种抗菌疗法的协同效应不理想以及需要高激光剂量等方面存在缺陷，从而影响了它们在眼部细菌感染治疗中的生物安全性。在此，一种温和的 PTT 纳米治疗平台是通过pH 响应吩噻嗪染料的自组装配制的。这些光热转换效率高达 84.5% 的有机纳米粒子仅需要 36 J/cm ^{2的超低光剂量}在 650 nm 激光照射下，在 pH 5.5 下实现高效的低温光热细菌抑制。此外，这种智能温和的光热纳米平台在酸性生物膜中经历了负电荷到正电荷的逆转，在光照射下表现出良好的穿透性和高效消除耐药大肠杆菌生物膜。进一步的体内动物试验表明，光热纳米粒子在眼部细菌感染治疗中具有有效的细菌消除和炎症缓解以及优异的生物相容性和生物安全性。总的来说，这种高效的单组分温和 PTT 系统具有简单的构建过程，具有广泛应用和临床转化的巨大潜力。

更新日期：2022-06-24

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