Pharmaceutical compounds were investigated in river and riverbank filtration (RBF) water at the Mosina-Krajkowo site (Poland), in 6 sampling campaigns between November 2019 and June 2020. All of the ten pharmaceutical compounds tested for were detected in the water. Carbamazepine, fluconazole, tramadol, sulphamethoxazole and sulphapyridine were the most frequently found, the highest concentrations being observed in surface water. There was a reduction in their levels in the horizontal well (HW) with drains located below the river bottom, averaging 17%. Significantly higher reductions (53–71%) were observed in vertical wells (VWs). Mixing, sorption and biodegradation were distinguished as processes conditioning the reduction of pharmaceutical compounds along flow paths from the river to the wells. Their reduction in the HW occurs due to sorption onto fine sediments with high organic matter content and aerobic biodegradation, while in the VWs it is the effect of aerobic biodegradation and water mixing with unpolluted groundwater. Sorption on riverbed fine sediments can also occur, especially during low water levels in the river. Biodegradation develops in oxic conditions with aerobic bacteria. VWs located at similar distances from the river yielded different concentrations of pharmaceutical compounds, because of differences in geological structure, hydrogeological conditions and well operation parameters.

在 2019 年 11 月至 2020 年 6 月期间的 6 次采样活动中，对 Mosina-Krajkowo 场地（波兰）的河流和河岸过滤 (RBF) 水中的药物化合物进行了调查。在水中检测到了所有测试的十种药物化合物。卡马西平、氟康唑、曲马多、磺胺甲恶唑和磺胺吡啶是最常见的，在地表水中观察到的浓度最高。水平井 (HW) 中的水位下降，排水沟位于河底下方，平均下降 17%。在垂直井 (VW) 中观察到显着更高的减少量 (53-71%)。混合、吸附和生物降解被区分为调节药物化合物沿着从河流到井的流动路径减少的过程。它们在 HW 中的减少是由于吸附到具有高有机物含量和好氧生物降解的细沉积物上，而在 VW 中，这是好氧生物降解和水与未污染地下水混合的影响。也会发生对河床细沉积物的吸附，尤其是在河流水位较低的情况下。生物降解在好氧条件下与好氧细菌一起发展。由于地质结构、水文地质条件和油井操作参数的差异，位于距离河流相似距离的大众汽车产生了不同浓度的药物化合物。尤其是在河流水位低的时候。生物降解在好氧条件下与好氧细菌一起发展。由于地质结构、水文地质条件和油井操作参数的差异，位于距离河流相似距离的大众汽车产生了不同浓度的药物化合物。尤其是在河流水位低的时候。生物降解在好氧条件下与好氧细菌一起发展。由于地质结构、水文地质条件和油井操作参数的差异，位于距离河流相似距离的大众汽车产生了不同浓度的药物化合物。