Ultrasmall AgBiSe2 nanodots for CT/thermal imaging-guided photothermal tumor therapy in the NIR-II biowindow,Nanoscale

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Ultrasmall AgBiSe2 nanodots for CT/thermal imaging-guided photothermal tumor therapy in the NIR-II biowindow
Nanoscale ( IF 5.8 ) Pub Date : 2022-06-24 , DOI: 10.1039/d2nr02908a
Jingge Zhang ₁ , Enna Ha ₁ , Danyang Li ₁ , Luyang Wang ₂ , Junqing Hu _{1,

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Affiliation

Stimulus-responsive ternary chalcogenide nanomaterials are regarded as promising ‘all-in-one’ nanotheranostics agents on account of their tunable band structures and multi-metal intrinsic properties. Herein, ultrasmall AgBiSe₂ nanodots are prepared by a simple thermal injection method. It shows a narrow band gap of 0.91 eV and high absorption coefficient in the NIR-II biowindow, resulting in excellent photothermal performance. Under the irradiation of a 1064 nm laser, AgBiSe₂ can induce the overexpression of intracellular heat shock protein (Hsp70) and cell apoptosis to inhibit the growth of tumor cells. The strong signal from CT/thermal imaging also provides guidance for tumor diagnosis. Importantly, AgBiSe₂ can be rapidly excreted from the body, thus avoiding long term toxicity. This study presents the first biomedical application of AgBiSe₂ nanodots in cancer treatment and extends the development of ternary chalcogenide-based semiconductor nanomedicine.

中文翻译：

在 NIR-II 生物窗中用于 CT/热成像引导的光热肿瘤治疗的超小型 AgBiSe2 纳米点

刺激响应的三元硫族化物纳米材料因其可调谐的能带结构和多金属固有特性而被认为是有前途的“一体化”纳米治疗剂。在此，超小AgBiSe ₂纳米点通过简单的热注入方法制备。它在 NIR-II 生物窗中显示出 0.91 eV 的窄带隙和高吸收系数，从而具有出色的光热性能。在1064 nm激光照射下，AgBiSe ₂可诱导细胞内热休克蛋白（Hsp70）过表达和细胞凋亡，从而抑制肿瘤细胞的生长。CT/热成像的强信号也为肿瘤诊断提供指导。重要的是，AgBiSe ₂能迅速从体内排出，从而避免长期中毒。本研究首次展示了 AgBiSe ₂纳米点在癌症治疗中的生物医学应用，并扩展了基于三元硫属化物的半导体纳米药物的开发。

更新日期：2022-06-24

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