Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh,Environment International

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Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh
Environment International ( IF 11.8 ) Pub Date : 2022-06-24 , DOI: 10.1016/j.envint.2022.107370
Liangmin Wei ₁ , Hui Huang ₁ , Xin Chen ₁ , Xiang Wang ₁ , Ruyang Zhang ₁ , Li Su ₂ , Weiwei Duan ₁ , Mahmudur Rahman ₃ , Md Golam Mostofa ₃ , Quazi Qamruzzaman ₃ , Hongbing Shen ₄ , Zhibin Hu ₄ , Yongyue Wei ₅ , David C Christiani ₆ , Feng Chen ₇

Affiliation

Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Dhaka Community Hospital Trust, Dhaka, Bangladesh.
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China.
Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China.
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China.

Background

Prenatal exposures to neurotoxic metals and trace elements are associated with early childhood neurodevelopmental outcomes. However, consequences of simultaneous exposure to mixtures of elements remain unclear.

Objective

To examine individual and joint effects of prenatal trace element exposure on early childhood neurodevelopment.

Methods

Using a well-established Bangladesh prospective birth cohort (2008–2011), we measured concentrations of 52 trace elements in umbilical cord serum of 569 mother–infant pairs using inductively coupled plasma mass spectrometry. Neurodevelopment was evaluated at 20–40 months of age using Bayley Scales of Infant and Toddler Development, Third Edition. Stability elastic net (ENET) was used to screen elements individually associated with the outcome; candidate exposures were combined by weighted linear combination to form a risk score representing their mixture effect on early childhood neurodevelopment.

Results

Stability ENET identified 15 trace elements associated with cognitive composite score and 14 associated with motor composite score, which were linearly combined to form the element risk score (ERS). Children with higher ERS_cognitive had lower probability of cognitive developmental delay (OR_{highest vs lowest}: 0.21; 95 %CI: 0.10, 0.40; P < 0.001; P_trend < 0.001). Children with ERS_motor in the top quintile had a significantly lower risk of motor developmental delay (OR: 0.16; 95 %CI: 0.09, 0.31; P < 0.001; P_trend < 0.001) versus the lowest quintile. In Bayesian kernel machine regression analyses, lithium [conditional posterior inclusion probability (cPIP) = 0.68], aluminum (cPIP = 0.83) and iron (cPIP = 1.00) contributed most to the lower cognitive composite score; zinc (cPIP = 1.00), silver (cPIP = 0.81), and antimony (cPIP = 0.65) mainly contributed to the change of motor composite score.

Conclusion

Co-exposure to lithium/aluminum/iron or zinc/silver/antimony appears to impact children’s neurodevelopment. ERS score reflecting maternal exposure could indicate children’s risk of neurodevelopmental delay, warranting further studies to explore the underlying mechanism.

中文翻译：

52 种微量元素的脐带血清元素组学与儿童早期神经发育：来自孟加拉国农村地区前瞻性出生队列的证据

背景

产前接触神经毒性金属和微量元素与儿童早期神经发育结果相关。然而，同时暴露于元素混合物的后果仍不清楚。

客观的

研究产前微量元素暴露对儿童早期神经发育的个体和联合影响。

方法

利用完善的孟加拉国前瞻性出生队列（2008-2011），我们使用电感耦合等离子体质谱法测量了 569 对母婴脐带血清中 52 种微量元素的浓度。使用贝利婴幼儿发育量表（第三版）对 20-40 个月大时的神经发育进行评估。使用稳定性弹性网（ENET）来筛选与结果单独相关的元素；通过加权线性组合将候选暴露组合起来，形成代表其对儿童早期神经发育的混合效应的风险评分。

结果

稳定性ENET确定了15种与认知综合评分相关的微量元素和14种与运动综合评分相关的微量元素，将它们线性组合形成元素风险评分（ERS）。_ERS认知较高的儿童出现认知发育迟缓的可能性较低（OR_{最高 vs 最低}：0.21；95%CI：0.10、0.40；P < 0.001；P_趋势 < 0.001）。_{与最低五分位数的 ERS运动}儿童相比，处于最高五分位数的 ERS 儿童运动发育迟缓的风险显着较低（OR：0.16；95%CI：0.09，0.31；P < 0.001；P_趋势 < 0.001）。在贝叶斯核机器回归分析中，锂[条件后验包含概率 (cPIP) = 0.68]、铝 (cPIP = 0.83) 和铁 (cPIP = 1.00) 对较低的认知综合得分贡献最大；锌(cPIP = 1.00)、银(cPIP = 0.81)和锑(cPIP = 0.65)对运动综合评分的变化有主要贡献。