Recent evidence highlights patients’ sex relevance in antitumor immune response through a complex interaction—among hormones, genes, behaviors, and the microbiome—that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy and toxicity of immune checkpoint inhibitors in solid tumors.

中文翻译：

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性与癌症免疫疗法：当前的理解和挑战

最近的证据强调，通过激素、基因、行为和微生物组之间复杂的相互作用，患者在抗肿瘤免疫反应中的性别相关性，影响先天和适应性免疫功能以及免疫逃避机制。这些复杂的相互作用最终影响免疫检查点抑制剂在实体瘤中的功效和毒性。