Interferons are potent antimicrobial effectors and thus an attractive target for pathogen interference. In this issue of Cell, Alphonse et al. reveal that the Shigella effectors OspC1 and OspC3 employ a surprising mechanism to block interferon signaling and attenuate antibacterial responses, thus securing their replicative niche.

中文翻译：

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志贺氏菌“Osp”对先天免疫的抑制

干扰素是有效的抗菌效应物，因此是病原体干扰的有吸引力的目标。在本期Cell中，Alphonse 等人。揭示志贺氏菌效应物 OspC1 和 OspC3 采用一种令人惊讶的机制来阻断干扰素信号传导并减弱抗菌反应，从而确保它们的复制生态位。