Enantioselective Friedel–Crafts Reaction of 2-Alkynyphenols with Aromatic Ethers by Chiral Brønsted Acid Catalysis,The Journal of Organic Chemistry

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Enantioselective Friedel–Crafts Reaction of 2-Alkynyphenols with Aromatic Ethers by Chiral Brønsted Acid Catalysis
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-06-24 , DOI: 10.1021/acs.joc.2c00762
Wenxuan Zhang ₁ , Jiaying Sun ₁ , Zhendong Lian ₁ , Ran Song ₁ , Daoshan Yang ₁ , Jian Lv ₁

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Herein, we report chiral strong Brønsted acid-catalyzed enantioselective Friedel–Crafts reaction of 2-alkynyphenols with aromatic ethers. The reaction affords the corresponding axially chiral styrenes in up to 91% yield and 97% ee.

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