Straightforward Synthesis of Alkyl Fluorides via Visible-Light-Induced Hydromono- and Difluoroalkylations of Alkenes with α-Fluoro Carboxylic Acids,The Journal of Organic Chemistry

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Straightforward Synthesis of Alkyl Fluorides via Visible-Light-Induced Hydromono- and Difluoroalkylations of Alkenes with α-Fluoro Carboxylic Acids
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-06-24 , DOI: 10.1021/acs.joc.2c00965
Chunfang Guo _{1,

2} , Xuliang Han ₁ , Yu Feng ₁ , Zhaolong Liu ₁ , Yueyun Li ₁ , Hui Liu ₁ , Lizhi Zhang ₁ , Yunhui Dong ₁ , Xinjin Li _{1,

3}

Affiliation

We herein report the first visible-light-induced hydromono- and difluoroalkylations of alkenes with inexpensive and easily accessible α-fluoro carboxylic acids. This metal-free protocol exhibits mild conditions, high efficiency, and excellent functional-group tolerance, providing a straightforward approach to mono- and difluoroalkylated alkanes. Moreover, the fluorine effect on the hydrofluoroalkylation reaction is discussed in detail.

中文翻译：

通过可见光诱导的烯烃与 α-氟代羧酸的氢单和二氟烷基化直接合成烷基氟化物

我们在此报告了第一个可见光诱导的烯烃与廉价且易于获得的 α-氟代羧酸的氢单和二氟烷基化反应。这种无金属协议表现出温和的条件、高效率和出色的官能团耐受性，为单氟烷基化烷烃和二氟烷基化烷烃提供了一种直接的方法。此外，详细讨论了氟对氢氟烷基化反应的影响。

更新日期：2022-06-24

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