Pocahemiketone A, a novel sesquiterpenoid possessing a unique spirocyclic skeleton with a hemiketal endoperoxide unit, was isolated from the essential oil of Pogostemon cablin. Its structure was determined by spectroscopic methods and single-crystal X-ray diffraction analyses. Pocahemiketone A exhibits a significant neuroprotective effect against Aβ_25–35-induced damage in SH-SY5Y cells by inhibiting NLRP3 inflammasome-mediated pyroptosis and oxidative stress. These results indicate that pocahemiketone A has great potential for use in the treatment of Alzheimer′s disease.

中文翻译：

---

Pocahemiketone A 是一种倍半萜类化合物，具有螺环骨架和半缩酮内过氧化物单元，可减轻 SH-SY5Y 细胞中 Aβ25-35 诱导的焦亡和氧化应激

Pocahemiketone A 是一种新型倍半萜类化合物，具有独特的螺环骨架和半缩酮内过氧化物单元，是从Pogostemon cablin的精油中分离得到的。其结构是通过光谱方法和单晶 X 射线衍射分析确定的。Pocahemiketone A通过抑制 NLRP3 炎性体介导的细胞焦亡和氧化应激，对 Aβ _25-35诱导的 SH-SY5Y 细胞损伤具有显着的神经保护作用。这些结果表明pocahemiketone A在治疗阿尔茨海默病方面具有巨大的潜力。