Silver-Catalyzed Carbon Dioxide Fixation on Alkynylindoles,Organic Letters

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Silver-Catalyzed Carbon Dioxide Fixation on Alkynylindoles
Organic Letters ( IF 4.9 ) Pub Date : 2022-06-24 , DOI: 10.1021/acs.orglett.2c01994
Seiya Uema ₁ , Kodai Saito ₁ , Tohru Yamada ₁

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A silver-catalyzed carbon dioxide fixation reaction into 2-alkynylindole derivatives was developed to afford tricyclic indoles. Carbon dioxide was selectively fixed on the N atom of the indole, and only 6-endo-dig cyclization proceeded under mild reaction conditions. Carboxylation on C3 of the indole was not observed. This method was applicable for a variety of 2-alkynylindoles, and the corresponding products were obtained in high yields without the production of side products.

中文翻译：

银催化二氧化碳固定在炔基吲哚上

开发了一种银催化的二氧化碳固定反应到 2-炔基吲哚衍生物中，以提供三环吲哚。二氧化碳选择性地固定在吲哚的N原子上，在温和的反应条件下仅进行6-endo-dig环化。没有观察到吲哚的 C3 上的羧基化。该方法适用于多种2-炔基吲哚类化合物，并以高收率得到相应产物，且不产生副产物。

更新日期：2022-06-24

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