Natural Polyphenols-Platinum Nanocomplexes Stimulate Immune System for Combination Cancer Therapy,Nano Letters

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Natural Polyphenols-Platinum Nanocomplexes Stimulate Immune System for Combination Cancer Therapy
Nano Letters ( IF 9.6 ) Pub Date : 2022-06-24 , DOI: 10.1021/acs.nanolett.2c02161
Jiajia Xiang _{1,

2,

3} , Yifan Zhang _{1,

3} , Xin Liu ₄ , Quan Zhou ₅ , Ying Piao _{1,

3} , Shiqun Shao _{1,

2,

3} , Jianbin Tang _{1,

2,

3} , Zhuxian Zhou _{1,

2,

3} , Tao Xie _{1,

2,

3} , Youqing Shen _{1,

2,

3}

Affiliation

Nanocarriers have been employed extensively to enhance drug delivery efficacy and reduce the side effect. However, carrier materials for drug delivery have challenging aspects, including safety concerns, low drug content, complexity in preparation, and low reproducibility. Herein, we propose a facile, universal, and green preparation way to use natural polyphenols to build platinum nanocomplex with stable structure, proper size, and high Pt content. The nanocomplexes are constructed by metal-polyphenol coordination using natural polyphenols and 1,2-diaminocyclohexane-Pt (II), enabling dual-responsive drug release behavior. For proof of concept, we demonstrate the antitumor activity of the Pt nanocomplex using a representative tannic acid-Pt nanocomplex (denoted as PTI). PTI can induce intensive tumor cell apoptosis, trigger immunogenic cell death (ICD), remarkably promote cytotoxic T lymphocytes (CTLs) infiltration in tumors, and significantly reduce immunosuppression of the tumor microenvironments, thus stimulating potent antitumor immune responses and showing effective antitumor activity by synergizing immune checkpoint blockade (ICB) therapy.

中文翻译：

天然多酚-铂纳米复合物刺激免疫系统用于联合癌症治疗

纳米载体已被广泛用于提高药物递送效率和减少副作用。然而，用于药物递送的载体材料具有挑战性的方面，包括安全性问题、药物含量低、制备复杂性和重现性低。在此，我们提出了一种简便、通用、绿色的制备方法，利用天然多酚构建结构稳定、尺寸合适、Pt含量高的铂纳米复合物。纳米复合物是通过金属-多酚配位使用天然多酚和 1,2-二氨基环己烷-Pt (II) 构建的，可实现双重响应的药物释放行为。为了证明概念，我们使用代表性的单宁酸-Pt 纳米复合物（表示为 PTI）证明了 Pt 纳米复合物的抗肿瘤活性。PTI可以诱导强烈的肿瘤细胞凋亡，

更新日期：2022-06-24

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