In the article by Ren et al. ‘Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging,” which published in the January 21, 2022 issue of the journal (Circ Res. 2022;130:252–272. doi: 10.1161/CIRCRESAHA.121.319044), the authors have requested a correction.

After concerns were raised in a PubPeer post about potential included duplicate images in figures and supplement uncut blots, the authors were contacted by the editors and asked to provide an explanation and original data and images. For Figure 3B, the authors state that the error was inadvertently introduced during the process of revision when an incorrect image of the PAR1WT/WT heart slice under APC treatment was inserted. The authors have provided a corrected Figure 3B. For Figure 6C, the authors state that the error was inadvertently introduced during the process of revision when an incorrect image of the western blot band for p-AMPK/AMPKα in the right panel of Figure 6C was used. The authors have provided a corrected Figure 6C. The errors in the supplemental uncut blots were introduced when preparing the files for publication and corrected versions have been provided in an updated supplemental file.

The authors apologize for the errors.

The corrected version of this article is available at https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.319044

在任等人的文章中。“活化蛋白 C 增强心脏对衰老中缺血性损伤的耐受性”，发表在 2022 年 1 月 21 日的期刊上 ( Circ Res . 2022;130:252–272.doi: 10.1161/CIRCRESAHA.121.319044)，作者有要求更正。

在 PubPeer 的一篇文章中提出了关于可能在图中包含重复图像和补充未切割印迹的问题后，编辑联系了作者并要求提供解释以及原始数据和图像。对于图 3B，作者指出，错误是在修订过程中无意中引入的，当时插入了 APC 治疗下的 PAR1WT/WT 心脏切片的错误图像。作者提供了一个更正的图 3B。对于图 6C，作者指出，当使用图 6C 右侧面板中 p-AMPK/AMPKα 的蛋白质印迹带的错误图像时，在修订过程中无意中引入了错误。作者提供了一个更正的图 6C。

作者为这些错误道歉。

本文的更正版本可在 https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.319044 获得