Nonmonotonic Relationship between the Oxidation State of Graphene-Based Materials and Its Cell Membrane Damage Effects,ACS Applied Materials & Interfaces

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Nonmonotonic Relationship between the Oxidation State of Graphene-Based Materials and Its Cell Membrane Damage Effects
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-06-24 , DOI: 10.1021/acsami.2c03520
Xiuhua Yin ₁ , Shitong Zhang ₂ , Ling Wen ₃ , Juan Su ₁ , Jian Huang ₄ , Guangxin Duan ₁ , Zaixing Yang ₁

Affiliation

With the rapid development of carbon-based two-dimensional nanomaterials in biomedical applications, growing concern has emerged regarding their biocompatibility and especially their interactions with cell membranes. Our experimental studies found that the oxidation state, as one of the most important chemical parameters of graphene derivatives, regulates the hemolysis effect on human red blood cells in a nonmonotonic manner. Scanning electron microscopy and optical microscopy observations suggested that graphene oxides with medium oxygen content have the most serious destructive effects on the cell membranes. Molecular dynamics simulations and potential of mean force calculations revealed that, on the one hand, with the decrease in the surface oxygenated groups, more sp² carbon area of graphene-based materials will be exposed, playing a facilitating role in the damage of cell membranes; on the other hand, fewer oxygenated groups also lead to the accumulation of graphene-based nanosheets in solutions. The formation of the multilayer structure of graphene-based nanosheets reduces the exposed sp² carbon area, prevents the collective extraction of lipid molecules, and eventually results in a weakened extraction effect on cell membranes. Together, these factors generate a nonmonotonic relationship between the oxidation state of graphene oxides and their destructive effects on cell membranes.

中文翻译：

石墨烯基材料氧化态与其细胞膜损伤效应的非单调关系

随着碳基二维纳米材料在生物医学应用中的快速发展，人们越来越关注它们的生物相容性，尤其是它们与细胞膜的相互作用。我们的实验研究发现，氧化态作为石墨烯衍生物最重要的化学参数之一，以非单调的方式调节对人体红细胞的溶血作用。扫描电镜和光学显微镜观察表明，中等氧含量的氧化石墨烯对细胞膜的破坏作用最为严重。分子动力学模拟和平均力计算的潜力表明，一方面，随着表面氧化基团的减少，更多的 sp ²石墨烯基材料的碳区会暴露出来，对细胞膜的损伤起到促进作用；另一方面，较少的氧化基团也会导致石墨烯基纳米片在溶液中的积累。石墨烯基纳米片多层结构的形成减少了暴露的sp ²碳面积，阻止了脂质分子的集体提取，最终导致对细胞膜的提取作用减弱。总之，这些因素在氧化石墨烯的氧化态与其对细胞膜的破坏性影响之间产生了非单调的关系。

更新日期：2022-06-24

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