The uncontrolled treatment process and high concentration of intracellular glutathione compromise the therapeutic efficacies of chemodynamic therapy (CDT). Here, iron oxide nanocrystals embedded in N-doped carbon nanosheets (IONCNs) are designed as a near-infrared light-triggered nanozyme for synergistic cascade tumor therapy. The IONCNs can absorb and convert 980 nm light to local heat, which induces the dissolution of iron oxide for generating Fe²⁺/Fe³⁺ in a weak acid environment, apart from thermal ablation of cancer cells. The formed Fe²⁺ takes on the active site for the Fenton reaction. The formed Fe³⁺ acts as glutathione peroxidase to magnify oxidative stress, improving the antitumor performance. The IONCNs can be used to visually track the treatment process via magnetic resonance imaging. Such IONCNs demonstrate great potential as an exogenously triggered nanozyme via an integrated cascade reaction for imaging-guided synergistic cancer therapy.

中文翻译：

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用于实时磁共振成像引导的协同级联肿瘤治疗的外源触发纳米酶

不受控制的治疗过程和高浓度的细胞内谷胱甘肽损害了化学动力学疗法 (CDT) 的治疗效果。在这里，嵌入 N 掺杂碳纳米片 (IONCN) 中的氧化铁纳米晶体被设计为用于协同级联肿瘤治疗的近红外光触发纳米酶。IONCNs 可以吸收 980 nm 光并将其转化为局部热量，从而在弱酸环境中诱导氧化铁溶解以生成 Fe ²⁺ /Fe ³⁺ ，同时对癌细胞进行热消融。形成的Fe ²⁺占据芬顿反应的活性位点。形成的 Fe ³⁺作为谷胱甘肽过氧化物酶放大氧化应激，提高抗肿瘤性能。IONCN 可用于通过磁共振成像在视觉上跟踪治疗过程。这种IONCNs通过整合级联反应作为外源触发的纳米酶表现出巨大的潜力，用于成像引导的协同癌症治疗。