Fabrication and Characterization of Antifungal Hydroxypropyl-β-Cyclodextrin/Pyrimethanil Inclusion Compound Nanofibers Based on Electrospinning,Journal of Agricultural and Food Chemistry

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Fabrication and Characterization of Antifungal Hydroxypropyl-β-Cyclodextrin/Pyrimethanil Inclusion Compound Nanofibers Based on Electrospinning
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-06-24 , DOI: 10.1021/acs.jafc.2c01866
Shuang Gao ₁ , Weiwei Feng ₁ , Han Sun ₁ , Lei Zong ₁ , Xiaoming Li ₁ , Lixia Zhao ₁ , Fei Ye ₁ , Ying Fu ₁

Affiliation

Pyrimethanil (PMT) is an anilinopyrimidine bactericide with poor water solubility, which limits its applications. To improve the physical and chemical properties of PMT, hydroxypropyl-β-cyclodextrin/pyrimethanil inclusion compound nanofibers (HPβCD/PMT-IC-NFs) were fabricated via electrospinning. A variety of analytical techniques were used to confirm the formation of the inclusion compound. Scanning electron microscopy image displayed that HPβCD/PMT-IC-NF was homogeneous without particles. Thermogravimetric analysis indicated that the formation of the inclusion compound improved the thermostability of PMT. In addition, the phase solubility test illustrated that the inclusion compound formed by PMT and HPβCD had a stronger water solubility. The antifungal effect test exhibited that HPβCD/PMT-IC-NF had better antifungal properties. The release experiment confirmed that HPβCD/PMT-IC-NF had a sustained-release effect, and the release curve conformed to the first-order kinetic model equation. In short, the fabrication HPβCD/PMT-IC-NF inhibited improved solubility and thermostability of PMT, thus promoting the development of pesticide dosage form to water-based and low-pollution direction.

中文翻译：

基于静电纺丝的抗真菌羟丙基-β-环糊精/嘧霉胺包合物纳米纤维的制备与表征

嘧霉胺（PMT）是一种苯胺嘧啶类杀菌剂，水溶性差，限制了其应用。为了改善 PMT 的物理和化学性能，通过静电纺丝制备了羟丙基-β-环糊精/嘧霉胺包合物纳米纤维（HPβCD/PMT-IC-NFs）。多种分析技术用于确认包合物的形成。扫描电镜图像显示 HPβCD/PMT-IC-NF 均匀，无颗粒。热重分析表明，包合物的形成提高了PMT的热稳定性。此外，相溶解度测试表明，PMT和HPβCD形成的包合物具有更强的水溶性。抗真菌作用试验表明HPβCD/PMT-IC-NF具有较好的抗真菌特性。释放实验证实HPβCD/PMT-IC-NF具有缓释作用，释放曲线符合一级动力学模型方程。总之，制备HPβCD/PMT-IC-NF抑制了PMT溶解度和热稳定性的提高，从而推动农药剂型向水性、低污染方向发展。

更新日期：2022-06-24

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