Using high-resolution molecular and optical mapping of the three-dimensional genome, we found that the transcription factor TCF-1 is linked to changes in the structure of topologically associating domains in T cell progenitors that lead to interactions between previously insulated regulatory elements and target genes at late stages of T cell development.

中文翻译：

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TCF-1 在 T 细胞发育过程中介导染色质混合

使用三维基因组的高分辨率分子和光学作图，我们发现转录因子 TCF-1 与 T 细胞祖细胞中拓扑关联结构域的结构变化有关，这些变化导致先前绝缘的调节元件和靶标之间的相互作用T 细胞发育后期的基因。