当前位置: X-MOL 学术Nat. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
TCF-1 mediates chromatin intermingling during T cell development
Nature Immunology ( IF 27.7 ) Pub Date : 2022-06-24 , DOI: 10.1038/s41590-022-01237-8


Using high-resolution molecular and optical mapping of the three-dimensional genome, we found that the transcription factor TCF-1 is linked to changes in the structure of topologically associating domains in T cell progenitors that lead to interactions between previously insulated regulatory elements and target genes at late stages of T cell development.

中文翻译:

TCF-1 在 T 细胞发育过程中介导染色质混合

使用三维基因组的高分辨率分子和光学作图,我们发现转录因子 TCF-1 与 T 细胞祖细胞中拓扑关联结构域的结构变化有关,这些变化导致先前绝缘的调节元件和靶标之间的相互作用T 细胞发育后期的基因。
更新日期:2022-06-24
down
wechat
bug