Catalytic Enantioselective Reductive Cross Coupling of Electron-Deficient Olefins,Organic Letters

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Catalytic Enantioselective Reductive Cross Coupling of Electron-Deficient Olefins
Organic Letters ( IF 4.9 ) Pub Date : 2022-06-23 , DOI: 10.1021/acs.orglett.2c01801
Kangning Cao _{1,

2} , Chunyang Li ₂ , Dong Tian ₂ , Xiaowei Zhao ₂ , Yanli Yin _{1,

3} , Zhiyong Jiang _{2,

3}

Affiliation

We report an enantioselective reductive cross coupling of electron-deficient olefins. Using a visible-light-driven cooperative photoredox and chiral Brønsted acid-catalyzed reaction with a Hantzsch ester as the terminal reductant, various cyclic and acyclic enones with 2-vinylpyridines were converted in high yields (up to 93%) to a wide range of enantioenriched pyridine derivatives featuring diverse γ-tertiary carbon stereocenters with good to excellent enantioselectivities (up to >99% ee).

中文翻译：

缺电子烯烃的催化对映选择性还原交叉偶联

我们报告了缺电子烯烃的对映选择性还原交叉偶联。使用可见光驱动的协同光氧化还原和手性布朗斯台德酸催化反应，以 Hantzsch 酯为末端还原剂，各种具有 2-乙烯基吡啶的环状和无环烯酮以高产率（高达 93%）转化为广泛的对映体富集的吡啶衍生物，具有多种 γ-叔碳立体中心，具有良好的对映选择性（高达 >99% ee）。

更新日期：2022-06-23

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