A new genome-wide polygenic risk score for chronic kidney disease (CKD) that combines APOL1 risk genotypes with polygenic effects was validated in 15 diverse cohorts. The top 2% of the score reproducibly conveyed a threefold higher risk of CKD across all ancestries, a degree of risk that is equivalent to a positive family history of kidney disease.

中文翻译：

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跨血统全基因组多基因评分预测慢性肾病

结合 APOL1 风险基因型和多基因效应的慢性肾脏病 (CKD) 新全基因组多基因风险评分在 15 个不同队列中得到验证。得分最高的 2% 可重复地传达出所有血统的 CKD 风险高出三倍，这一风险程度相当于肾病阳性家族史。