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Electromembrane Extraction and Dual-Channel Nanoelectrospray Ionization Coupled with a Miniature Mass Spectrometer: Incorporation of a Dicationic Ionic Liquid-Induced Charge Inversion Strategy
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-06-23 , DOI: 10.1021/acs.analchem.2c01921 Meng Chen 1 , Yuhan Shang 1 , Hua Bai 1 , Qiang Ma 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-06-23 , DOI: 10.1021/acs.analchem.2c01921 Meng Chen 1 , Yuhan Shang 1 , Hua Bai 1 , Qiang Ma 1
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Green analytical chemistry aims at developing analytical methods with minimum use and generation of hazardous substances for the protection of human health and the environment. To address this need, a green analytical protocol has been developed for the analysis of anionic compounds integrating electromembrane extraction (EME), dual-channel nanoelectrospray ionization (nanoESI), and a miniature mass spectrometer. Haloacetic acids (HAAs) have attracted considerable public concern due to their adverse effects on human health and were selected as model analytes for method development. A flat membrane EME device was developed and assembled in-house. Optimization of fundamental operational parameters was performed using single-factor test and response surface methodology. Both the EME acceptor phase and an imidazolium-based dicationic ionic liquid (DIL), 1,1-bis(3-methylimidazolium-1-yl) butylene difluoride (C4(MIM)2F2), were subjected to dual-channel nanoESI and miniature mass spectrometry analysis based on a charge inversion strategy, where positively charged complexes were formed. Enhancement in signal intensity by as much as 2 magnitudes was achieved in the positive-ion mode compared to the negative-ion mode in the absence of the dicationic ion-pairing agent. The developed protocol was validated, obtaining good recoveries ranging from 82.7 to 109.9% and satisfactory sensitivity with limits of detection (LODs) and quantitation (LOQs) in the ranges of 1–5 and 2–10 μg/L, respectively. The greenness of the analytical procedure was assessed with a calculated score of 0.71, indicating a high degree of greenness. The developed method was applied to the analysis of real environmental or municipal water samples (n = 16), exhibiting appealing potential for outside-the-laboratory applications.
中文翻译：
电膜萃取和双通道纳米电喷雾电离与微型质谱仪相结合：结合双离子液体诱导电荷反转策略
绿色分析化学旨在开发分析方法，尽量减少有害物质的使用和产生，以保护人类健康和环境。为了满足这一需求，已经开发出一种绿色分析方案，用于分析阴离子化合物，集成电膜萃取 (EME)、双通道纳米电喷雾电离 (nanoESI) 和微型质谱仪。卤代乙酸 (HAA) 因其对人体健康的不利影响而引起了公众的广泛关注，并被选为方法开发的模型分析物。平板膜 EME 设备是在内部开发和组装的。使用单因素测试和响应面方法对基本操作参数进行了优化。4 (MIM) 2楼2），基于电荷反转策略进行双通道纳米ESI和微型质谱分析，其中形成带正电荷的配合物。与不存在双阳离子离子对试剂的负离子模式相比，在正离子模式中实现了多达 2 个数量级的信号强度增强。所开发的方案经过验证，获得了 82.7 至 109.9% 的良好回收率和令人满意的灵敏度，检测限 (LOD) 和定量 (LOQ) 分别在 1-5 和 2-10 μg/L 范围内。以 0.71 的计算分数评估分析程序的绿色度，表明高度的绿色度。所开发的方法应用于实际环境或市政水样的分析（n= 16），表现出对实验室外应用的吸引力。
更新日期：2022-06-23
中文翻译：
电膜萃取和双通道纳米电喷雾电离与微型质谱仪相结合：结合双离子液体诱导电荷反转策略
绿色分析化学旨在开发分析方法，尽量减少有害物质的使用和产生，以保护人类健康和环境。为了满足这一需求，已经开发出一种绿色分析方案，用于分析阴离子化合物，集成电膜萃取 (EME)、双通道纳米电喷雾电离 (nanoESI) 和微型质谱仪。卤代乙酸 (HAA) 因其对人体健康的不利影响而引起了公众的广泛关注，并被选为方法开发的模型分析物。平板膜 EME 设备是在内部开发和组装的。使用单因素测试和响应面方法对基本操作参数进行了优化。4 (MIM) 2楼2），基于电荷反转策略进行双通道纳米ESI和微型质谱分析，其中形成带正电荷的配合物。与不存在双阳离子离子对试剂的负离子模式相比，在正离子模式中实现了多达 2 个数量级的信号强度增强。所开发的方案经过验证，获得了 82.7 至 109.9% 的良好回收率和令人满意的灵敏度，检测限 (LOD) 和定量 (LOQ) 分别在 1-5 和 2-10 μg/L 范围内。以 0.71 的计算分数评估分析程序的绿色度，表明高度的绿色度。所开发的方法应用于实际环境或市政水样的分析（n= 16），表现出对实验室外应用的吸引力。
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