Well-Defined [Cp*Co(N,O)I]-Catalysts for Site-Selective Intramolecular C−H Amidation,Advanced Synthesis & Catalysis

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Well-Defined [Cp*Co(N,O)I]-Catalysts for Site-Selective Intramolecular C−H Amidation
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-06-22 , DOI: 10.1002/adsc.202200385
Pardeep Dahiya ₁ , Ankita Sarkar ₁ , Basker Sundararaju ₁

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We present an efficient method for forming C−N bonds via intramolecular amidation catalyzed by well-defined Cp*Co(N,O)I complexes. The reaction has been operate under mild conditions and produced a regioselective amidation product without the use of a bulky counter anion or expensive fluorinated solvents. The Cp*Co(N,O)-I catalyst is very effective for intramolecular benzylic, tertiary, and internal C(sp³)−H bond amidation, but ineffective for intramolecular C(sp²)−H bond amidation.

中文翻译：

用于位点选择性分子内 C-H 酰胺化的明确 [Cp*Co(N,O)I]-催化剂

我们提出了一种通过定义明确的 Cp*Co(N,O)I 配合物催化的分子内酰胺化形成 C-N 键的有效方法。该反应在温和的条件下进行，并在不使用庞大的抗衡阴离子或昂贵的氟化溶剂的情况下产生了区域选择性酰胺化产物。Cp*Co(N,O)-I催化剂对分子内苄基、叔和内部C( sp ³ )-H键酰胺化非常有效，但对分子内C( sp ² )-H键酰胺化无效。

更新日期：2022-06-22

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