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Access to Sulfocoumarins by Three-Component Reaction of β-Keto Sulfonyl Fluorides, Arynes, and DMF
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-06-21 , DOI: 10.1002/ejoc.202200715
Yuan Huang 1 , Xueyan Zhao 1 , Dengfeng Chen 1 , Yu Zheng 2 , Jinyue Luo 1 , Shenlin Huang 3
Affiliation  

A novel synthesis of sulfocoumarins by three-component reaction of β-keto sulfonyl fluorides, arynes and DMF is reported. The reaction proceeds via trapping of the in situ generated o-quinone methides with β-keto sulfonyl fluorides, followed by selective cyclization with sulfonyl fluorides. This strategy provides a new avenue to access diverse sulfocoumarins under mild conditions.

中文翻译:

通过 β-酮磺酰氟、芳烃和 DMF 的三组分反应获得磺基香豆素

报道了一种通过 β-酮基磺酰氟、芳烃和 DMF 的三组分反应合成磺基香豆素的新方法。该反应通过用β-酮基磺酰氟捕获原位产生的邻醌甲基化物进行,然后用磺酰氟选择性环化。该策略为在温和条件下获取多种磺基香豆素提供了新途径。
更新日期:2022-06-21
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