Surface Engineering of Laser-Induced Graphene Enables Long-Term Monitoring of On-Body Uric Acid and pH Simultaneously,Nano Letters

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Surface Engineering of Laser-Induced Graphene Enables Long-Term Monitoring of On-Body Uric Acid and pH Simultaneously
Nano Letters ( IF 9.6 ) Pub Date : 2022-06-22 , DOI: 10.1021/acs.nanolett.2c01500
Liqiang Zhang ₁ , Lang Wang ₁ , Jiye Li ₁ , Can Cui ₂ , Ziqian Zhou ₁ , Liaoyong Wen ₁

Affiliation

Laser-induced graphene (LIG) suffers from serious decay in long-term biosensing, which greatly restricts its practical applications. Herein, we report a new strategy to engineer the LIG surface with Au clusters and chitosan sequentially to form a C–Au–LIG electrode with a superhydrophilic and highly conductive 3D graphene surface, which demonstrates superior performance and negligible decay in both long-term storage and practical usage in vitro and in vivo environments. Moreover, the C–Au–LIG electrode can be used for detecting uric acid (UA) and pH simultaneously from a single differential pulse voltammetry curve with low-detection limitation, high accuracy, and negligible interference with other sweat biomarkers. The integrated C–Au–LIG wearable biosensor was employed to continuously monitor the UA content in human sweat, which can well reflect the daily intake of purines for at least 10 days. Therefore, the C–Au–LIG electrode demonstrates significant application potential and provides inspiration for surface engineering of other biosensor materials and electrodes.

中文翻译：

激光诱导石墨烯的表面工程可同时长期监测体内尿酸和 pH 值

激光诱导石墨烯（LIG）在长期生物传感中存在严重衰减，极大地限制了其实际应用。在这里，我们报告了一种新的策略，用 Au 簇和壳聚糖依次设计 LIG 表面，以形成具有超亲水性和高导电性 3D 石墨烯表面的 C-Au-LIG 电极，这在长期存储中表现出优异的性能和可忽略不计的衰减以及在体外和体内环境中的实际使用。此外，C-Au-LIG 电极可用于从单个微分脉冲伏安曲线同时检测尿酸 (UA) 和 pH 值，检测限制低、准确度高且对其他汗液生物标志物的干扰可忽略不计。集成的 C-Au-LIG 可穿戴生物传感器用于连续监测人体汗液中的 UA 含量，可以很好地反映至少10天每天的嘌呤摄入量。因此，C-Au-LIG 电极显示出巨大的应用潜力，并为其他生物传感器材料和电极的表面工程提供了灵感。

更新日期：2022-06-22

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