Living materials are worked as an inside collaborative system that could naturally respond to changing environmental conditions. The regulation of bioelectronic processes in living materials could be effective for collecting biological signals and detecting biomarkers. Here, we constructed a living material with conjugated polymers poly[3-(3′- N , N , N -triethylamino-1′-propyloxy)-4-methyl-2,5-thiophene chloride] (PMNT) and Shewanella oneidensis MR-1 biofilm. In addition, the living material was integrated as a flexible bioelectronic device for lactate detection in physiological fluids (sweat, urine, and plasma). Owing to the electroconductivity of conjugated polymers, PMNT could optimize the bioelectronic process in the living material. The collected electrical signal could be wirelessly transferred to a portable smartphone for reading and analyzing. Because lactate is also a biomarker for cancer treatment, the flexible bioelectronic device was further used to detect and count the cancer cells. The proof of the bioelectronic device using conductive polymer–based living material exhibits promising applications in the next-generation personal health monitoring systems.

中文翻译：

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由导电聚合物基活体材料制造的柔性生物电子器件

生活材料作为一个内部协作系统工作，可以自然地响应不断变化的环境条件。生物材料中生物电子过程的调节可以有效地收集生物信号和检测生物标志物。在这里，我们用共轭聚合物 poly[3-(3'-ñ,ñ,ñ-三乙氨基-1'-丙氧基）-4-甲基-2,5-噻吩氯化物]（PMNT）和奥奈德希瓦氏菌MR-1 生物膜。此外，这种活体材料被集成为一种灵活的生物电子设备，用于检测生理液体（汗液、尿液和血浆）中的乳酸。由于共轭聚合物的导电性，PMNT 可以优化生物材料中的生物电子过程。收集的电信号可以无线传输到便携式智能手机进行读取和分析。由于乳酸也是癌症治疗的生物标志物，因此这种柔性生物电子设备被进一步用于检测和计数癌细胞。使用基于导电聚合物的生物材料的生物电子设备的证明在下一代个人健康监测系统中展示了有希望的应用。