Chronic and non-healing wounds pose a great challenge to clinical management and patients. Many studies have explored novel interventions against skin wounds, with bioactive peptides, nanoparticles, and hydrogels arousing considerable attention regarding their therapeutic potential. In this study, the prohealing peptide RL-QN15 was loaded into hollow silica nanoparticles (HSNs), with these HSN@RL-QN15 nanocomposites then combined with zinc alginate (ZA) gels to obtain HSN@RL-QN15/ZA hydrogel. The characteristics, biological properties, and safety profiles of the hydrogel composites were then evaluated. Results showed that the hydrogel had good porosity, hemocompatibility, biocompatibility, and broad-spectrum antimicrobial activity, with the slow release of loaded RL-QN15. Further analysis indicated that the hydrogel promoted skin cell proliferation and keratinocyte scratch repair, regulated angiogenesis, reduced inflammation, and accelerated re-epithelialization and granulation tissue formation, resulting in the rapid healing of both full-thickness skin wounds and methicillin-resistant Staphylococcus aureus biofilm-infected chronic wounds in mice. This peptide-based hydrogel provides a novel intervention for the treatment of chronic skin wounds and shows promise as a wound dressing in the field of tissue regeneration.

中文翻译：

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载有 RL-QN15 肽的 Zn2+ 交联海藻酸盐携带空心二氧化硅纳米粒子为慢性皮肤伤口提供有希望的治疗

慢性和不愈合伤口对临床管理和患者提出了巨大挑战。许多研究探索了针对皮肤伤口的新型干预措施，生物活性肽、纳米颗粒和水凝胶引起了人们对其治疗潜力的极大关注。在这项研究中，将促愈合肽 RL-QN15 加载到中空二氧化硅纳米粒子 (HSN) 中，然后将这些 HSN@RL-QN15 纳米复合材料与海藻酸锌 (ZA) 凝胶结合以获得 HSN@RL-QN15/ZA 水凝胶。然后评估水凝胶复合材料的特性、生物学特性和安全性。结果表明，该水凝胶具有良好的孔隙率、血液相容性、生物相容性和广谱抗菌活性，负载的RL-QN15释放缓慢。小鼠金黄色葡萄球菌生物膜感染的慢性伤口。这种基于肽的水凝胶为治疗慢性皮肤伤口提供了一种新的干预措施，并有望成为组织再生领域的伤口敷料。