Antimicrobial resistance (AMR) is a grand societal challenge with important dimensions in the water environment that contribute to its evolution and spread. Environmental monitoring could provide vital information for mitigating the spread of AMR; this includes assessing antibiotic resistance genes (ARGs) circulating among human populations, identifying key hotspots for evolution and dissemination of resistance, informing epidemiological and human health risk assessment models, and quantifying removal efficiencies by domestic wastewater infrastructure. However, standardized methods for monitoring AMR in the water environment will be vital to producing the comparable data sets needed to address such questions. Here we sought to establish scientific consensus on a framework for such standardization, evaluating the state of the science and practice of AMR monitoring of wastewater, recycled water, and surface water, through a literature review, survey, and workshop leveraging the expertise of academic, governmental, consulting, and water utility professionals.

中文翻译：

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水环境的抗菌药物耐药性监测：标准化方法和质量控制框架


抗菌素耐药性 (AMR) 是一项重大社会挑战，在水环境中具有重要影响，有助于其演变和传播。环境监测可以为减轻抗菌素耐药性的传播提供重要信息；这包括评估人群中循环的抗生素抗性基因（ARG），确定抗性进化和传播的关键热点，为流行病学和人类健康风险评估模型提供信息，以及量化家庭废水基础设施的去除效率。然而，监测水环境中抗菌素耐药性的标准化方法对于生成解决此类问题所需的可比数据集至关重要。在此，我们寻求就此类标准化框架建立科学共识，通过文献综述、调查和研讨会，利用学术界的专业知识，评估废水、再生水和地表水 AMR 监测的科学状况和实践。政府、咨询和水务专业人员。