Background:Exercise has profound effects on cardiovascular function and metabolism in both physiological and pathophysiological states. The present study tested whether voluntary exercise would protect male offspring against maternal gestational hypertension-induced hypertensive response sensitization elicited by post-weaning high-fat diet (HFD).Methods And Results:On low-lard-fat diet, offspring of both normotensive and hypertensive dams had comparable resting blood pressure, but HFD feeding elicited an enhanced increase in blood pressure (ie, hypertensive response sensitization) in sedentary offspring of hypertensive dams when compared with sedentary offspring of normotensive dams. The HFD fed sedentary offspring of hypertensive dams displayed greater sympathetic activity, enhanced pressor responses to centrally administered ANG II (angiotensin II) or leptin, and greater mRNA expression of proinflammatory cytokines, leptin, and a marker of blood-brain barrier leakage in the hypothalamic paraventricular nucleus. The enhanced blood pressure and central sympathetic activity in HFD-fed sedentary offspring of hypertensive dams were significantly reduced by exercise but fell only to levels comparable to HFD-fed exercising offspring of normotensive dams. HFD-induced increases in plasma IL-6 (interleukin-6) and sympathetic activity and greater pressor responses to central TNF (tumor necrosis factor)-α in offspring from both normotensive and hypertensive dams were also maintained after exercise. Nevertheless, exercise had remarkably beneficial effects on metabolic and autonomic function, brain reactivity to ANG II and leptin and gene expression of brain prohypertensive factors in all offspring.Conclusions:Voluntary exercise plays a beneficial role in preventing maternal hypertension-induced hypertensive response sensitization, and that this is associated with attenuation of enhanced brain reactivity and centrally driven sympathetic activity.

中文翻译：

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自愿运动消除了母亲妊娠期高血压引起的男性成年后代对断奶后高脂肪饮食的高血压反应敏感性

背景：运动对生理和病理生理状态下的心血管功能和代谢都有深远的影响。本研究测试了自愿锻炼是否可以保护雄性后代免受断奶后高脂饮食（HFD）引起的母体妊娠高血压诱发的高血压反应敏化。方法和结果：在低猪油脂肪饮食下，正常血压和高血压母鼠的静息血压相当，但与血压正常母鼠久坐的后代相比，高脂饮食喂养会导致高血压母鼠久坐的后代血压升高（即高血压反应敏化）。HFD喂养的高血压母鼠的久坐后代表现出更强的交感神经活性，对集中施用的ANG II（血管紧张素II）或瘦素的升压反应增强，以及促炎细胞因子、瘦素和下丘脑血脑屏障渗漏标志物的mRNA表达更高室旁核。运动后，高脂饮食喂养的高血压母鼠久坐后代的血压和中枢交感神经活性显着降低，但仅下降到与高脂饮食喂养的正常血压母鼠运动后代相当的水平。运动后，正常血压和高血压母鼠的后代中，HFD 诱导的血浆 IL-6（白细胞介素 6）和交感神经活性增加，以及对中枢 TNF（肿瘤坏死因子）-α 的升压反应增强，这些现象也得以维持。尽管如此，运动对所有后代的代谢和自主功能、大脑对 ANG II 和瘦素的反应性以及脑部高血压因子的基因表达具有显着的有益影响。这与增强的大脑反应性和中枢驱动的交感神经活动的减弱有关。