Construction of N-Polyheterocycles by N-Heterocyclic Carbene Catalysis via a Regioselective Intramolecular Radical Addition/Cyclization Cascade,Organic Letters

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Construction of N-Polyheterocycles by N-Heterocyclic Carbene Catalysis via a Regioselective Intramolecular Radical Addition/Cyclization Cascade
Organic Letters ( IF 4.9 ) Pub Date : 2022-06-22 , DOI: 10.1021/acs.orglett.2c01729
Qijing Zhang ₁ , Hao Lei ₁ , Cong-Ying Zhou ₁ , Chengming Wang _{1,

2}

Affiliation

N-Polyheterocycles are rapidly accessed by N-heterocyclic carbene (NHC) catalysis through regioselective sequential radical addition/cyclization in the absence of any metals or oxidants. The transformation occurs under mild conditions and enjoys a wide substrate scope with excellent functional group compatibility. Furthermore, a gram-scale synthesis is also conducted. Preliminary mechanistic studies reveal the potential involvement of an NHC radical cation intermediate.

中文翻译：

N-杂环卡宾催化区域选择性分子内自由基加成/环化级联构建N-多杂环

在不存在任何金属或氧化剂的情况下，通过N-杂环卡宾 (NHC) 催化通过区域选择性顺序自由基加成/环化快速获得N-多杂环。转化条件温和，底物范围广，官能团相容性好。此外，还进行了克级合成。初步机理研究揭示了 NHC 自由基阳离子中间体的潜在参与。

更新日期：2022-06-22

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