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Functional Shape-Morphing Microarchitectures Fabricated by Dynamic Holographically Shifted Femtosecond Multifoci
Nano Letters ( IF 9.6 ) Pub Date : 2022-06-21 , DOI: 10.1021/acs.nanolett.2c01178 Leran Zhang 1 , Bingrui Liu 1 , Chaowei Wang 1 , Chen Xin 1 , Rui Li 1 , Dawei Wang 1 , Liqun Xu 1 , Shengying Fan 1 , Juan Zhang 1 , Chenchu Zhang 2 , Yanlei Hu 1 , Jiawen Li 1 , Dong Wu 1 , Li Zhang 3 , Jiaru Chu 1
Nano Letters ( IF 9.6 ) Pub Date : 2022-06-21 , DOI: 10.1021/acs.nanolett.2c01178 Leran Zhang 1 , Bingrui Liu 1 , Chaowei Wang 1 , Chen Xin 1 , Rui Li 1 , Dawei Wang 1 , Liqun Xu 1 , Shengying Fan 1 , Juan Zhang 1 , Chenchu Zhang 2 , Yanlei Hu 1 , Jiawen Li 1 , Dong Wu 1 , Li Zhang 3 , Jiaru Chu 1
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Functional microdevices based on responsive hydrogel show great promise in targeted delivery and biomedical analysis. Among state-of-the-art techniques for manufacturing hydrogel-based microarchitectures, femtosecond laser two-photon polymerization distinguishes itself by high designability and precision, but the point-by-point writing scheme requires mechanical apparatuses to support focus scanning. In this work, by predesigning holograms combined with lens phase modulation, multiple femtosecond laser spots are holographically generated and shifted for prototyping of three-dimensional shape-morphing structures without any moving equipment in the construction process. The microcage array is rapidly fabricated for high-performance target capturing enabled by switching environmental pH. Moreover, the built scaffolds can serve as arrayed analytical platforms for observing cell behaviors in normal or changeable living spaces or revealing the anticancer effects of loaded drugs. The proposed approach opens a new path for facile and flexible manufacturing of hydrogel-based functional microstructures with great versatility in micro-object manipulation.
中文翻译：
由动态全息移动飞秒多焦点制造的功能性形状变形微架构
基于响应性水凝胶的功能性微器件在靶向递送和生物医学分析中显示出巨大的前景。在制造基于水凝胶的微结构的最先进技术中，飞秒激光双光子聚合以其高可设计性和精度而著称，但逐点写入方案需要机械设备来支持焦点扫描。在这项工作中，通过预先设计全息图并结合透镜相位调制，在构建过程中无需任何移动设备即可全息生成和移动多个飞秒激光光斑，用于三维形状变形结构的原型制作。微笼阵列可快速制造，可通过切换环境 pH 值实现高性能目标捕获。而且，构建的支架可以作为阵列分析平台，用于观察正常或多变生活空间中的细胞行为或揭示装载药物的抗癌作用。所提出的方法为轻松灵活地制造基于水凝胶的功能微结构开辟了一条新途径，在微物体操作中具有很大的多功能性。
更新日期：2022-06-21
中文翻译：
由动态全息移动飞秒多焦点制造的功能性形状变形微架构
基于响应性水凝胶的功能性微器件在靶向递送和生物医学分析中显示出巨大的前景。在制造基于水凝胶的微结构的最先进技术中，飞秒激光双光子聚合以其高可设计性和精度而著称，但逐点写入方案需要机械设备来支持焦点扫描。在这项工作中，通过预先设计全息图并结合透镜相位调制，在构建过程中无需任何移动设备即可全息生成和移动多个飞秒激光光斑，用于三维形状变形结构的原型制作。微笼阵列可快速制造，可通过切换环境 pH 值实现高性能目标捕获。而且，构建的支架可以作为阵列分析平台，用于观察正常或多变生活空间中的细胞行为或揭示装载药物的抗癌作用。所提出的方法为轻松灵活地制造基于水凝胶的功能微结构开辟了一条新途径，在微物体操作中具有很大的多功能性。
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