Epidemiological studies have identified the role of periodontitis in the pathogenesis of type 2 diabetes, but the underlying mechanism is poorly understood. It is well-known that small extracellular vesicles are lipid bilayer vesicles derived from cells with a diameter around 30 to 200 nm. The purpose of this study was to investigate whether periodontitis induced or exacerbated insulin resistance via circulating small extracellular vesicles.

中文翻译：

---

来自牙周炎患者的循环小细胞外囊泡有助于胰岛素抵抗的发展

流行病学研究已经确定了牙周炎在 2 型糖尿病发病机制中的作用，但对其潜在机制知之甚少。众所周知，小细胞外囊泡是源自细胞的脂质双层囊泡，直径约为 30 至 200 nm。本研究的目的是调查牙周炎是否通过循环小细胞外囊泡诱导或加剧胰岛素抵抗。