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Comprehensive Review of γ-Glutamyl Peptides (γ-GPs) and Their Effect on Inflammation Concerning Cardiovascular Health
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-06-21 , DOI: 10.1021/acs.jafc.2c01712 Snigdha Guha 1 , Kaustav Majumder 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-06-21 , DOI: 10.1021/acs.jafc.2c01712 Snigdha Guha 1 , Kaustav Majumder 1
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γ-Glutamyl peptides (γ-GPs) are a group of peptides naturally found in various food sources. The unique γ-bond potentially enables them to resist gastrointestinal digestion and offers high stability in vivo with a longer half-life. In recent years, these peptides have caught researchers’ attention due to their ability to impart kokumi taste and elicit various physiological functions via the allosteric activation of the calcium-sensing receptor (CaSR). This review discusses the various food sources of γ-glutamyl peptides, different synthesis modes, allosteric activation of CaSR for taste perception, and associated multiple biological functions they can exhibit, with a special emphasis on their role in modulating chronic inflammation concerning cardiovascular health.
中文翻译：
γ-谷氨酰肽 (γ-GPs) 及其对心血管健康炎症的影响的综合评价
γ-谷氨酰肽 (γ-GPs) 是一组天然存在于各种食物来源中的肽。独特的 γ 键可能使它们能够抵抗胃肠消化，并在体内提供高稳定性和更长的半衰期。近年来，这些肽因其能够通过钙敏感受体（CaSR）的变构激活而赋予kokumi味道并引发各种生理功能而引起了研究人员的关注。这篇综述讨论了 γ-谷氨酰肽的各种食物来源、不同的合成模式、CaSR 的味觉变构激活以及它们可以表现出的相关多种生物学功能，特别强调了它们在调节与心血管健康有关的慢性炎症中的作用。
更新日期：2022-06-21
中文翻译：
γ-谷氨酰肽 (γ-GPs) 及其对心血管健康炎症的影响的综合评价
γ-谷氨酰肽 (γ-GPs) 是一组天然存在于各种食物来源中的肽。独特的 γ 键可能使它们能够抵抗胃肠消化，并在体内提供高稳定性和更长的半衰期。近年来，这些肽因其能够通过钙敏感受体（CaSR）的变构激活而赋予kokumi味道并引发各种生理功能而引起了研究人员的关注。这篇综述讨论了 γ-谷氨酰肽的各种食物来源、不同的合成模式、CaSR 的味觉变构激活以及它们可以表现出的相关多种生物学功能，特别强调了它们在调节与心血管健康有关的慢性炎症中的作用。
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