Enantioselective Dual Catalysis of N-Heterocyclic Carbene and Hydrogen-Bond Donor Organocatalysts,European Journal of Organic Chemistry

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Enantioselective Dual Catalysis of N-Heterocyclic Carbene and Hydrogen-Bond Donor Organocatalysts
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-06-20 , DOI: 10.1002/ejoc.202200548
Hongling Wang ₁ , Yonggui Robin Chi ₂ , Xuan Huang ₁

Affiliation

The combination of N-heterocyclic carbene and hydrogen-bond donor enables new modes of reactivity not previously available by using either catalyst alone. Clever selection of hydrogen-bond donor can lead to increased yields, enhanced reactivity, and improved stereoselectivity. This minireview summarized the advances of bifunctional NHC and some of the development of NHC and hydrogen-bond donor for dual catalytic enantioselective reactions.

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