Massive virtual screenings with a focus on SARS-CoV-2 are now available in the literature. Unfortunately, standard implementations without further refinements and/or biological assays have shown a limited impact in real clinical applications. To guide next computational efforts, herein we combine theory and experiments to critically assess pros and cons of such methods.

中文翻译：

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当虚拟筛选产生无活性药物时：应对虚假的理论朋友

现在文献中已有针对 SARS-CoV-2 的大规模虚拟筛查。不幸的是，未经进一步改进和/或生物测定的标准实施在实际临床应用中的影响有限。为了指导下一步的计算工作，我们结合理论和实验来批判性地评估此类方法的优缺点。