Bacterial Butyrate in Parkinson's Disease Is Linked to Epigenetic Changes and Depressive Symptoms,Movement Disorders

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Bacterial Butyrate in Parkinson's Disease Is Linked to Epigenetic Changes and Depressive Symptoms
Movement Disorders ( IF 8.6 ) Pub Date : 2022-06-20 , DOI: 10.1002/mds.29128
Aoji Xie ₁ , Elizabeth Ensink ₁ , Peipei Li ₁ , Juozas Gordevičius ₁ , Lee L Marshall ₁ , Sonia George ₁ , John Andrew Pospisilik ₂ , Velma T E Aho _{3,

4} , Madelyn C Houser _{5,

6} , Pedro A B Pereira _{3,

4} , Knut Rudi ₇ , Lars Paulin ₄ , Malú G Tansey _{6,

8} , Petri Auvinen ₄ , Patrik Brundin _{1,

9} , Lena Brundin _{1,

9} , Viviane Labrie _{1,

9} , Filip Scheperjans ₃

Affiliation

Department for Neurodegenerative Science, Parkinson's Disease Center, Van Andel Institute, Grand Rapids, Michigan, USA.
Center for Epigenetics, Van Andel Institute, Grand Rapids, Michigan, USA.
Department of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Helsinki, Finland.
Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland.
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA.
Department of Physiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Faculty of Chemistry, Biotechnology and Food Science (KBM), Norwegian University of Life Sciences, Ås, Norway.
Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, Florida, USA.
Division of Psychiatry and Behavioral Medicine, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.

The gut microbiome and its metabolites can impact brain health and are altered in Parkinson's disease (PD) patients. It has been recently demonstrated that PD patients have reduced fecal levels of the potent epigenetic modulator butyrate and its bacterial producers.

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