Antigen loading onto class I major histocompatibility complex (MHC-I) proteins relies on chaperones and protein flexibility. Researchers now provide new insight into the process, especially for the intriguing ‘non-classical’ MHC-I protein MR1, with implications for fundamental immunology and the development of novel immunotherapies.

中文翻译：

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陪伴抗原呈递的舞蹈

I 类主要组织相容性复合物 (MHC-I) 蛋白上的抗原负载依赖于伴侣蛋白和蛋白质的灵活性。研究人员现在提供了对该过程的新见解，特别是对于有趣的“非经典”MHC-I 蛋白 MR1，这对基础免疫学和新型免疫疗法的开发具有重要意义。