Well-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines,The Journal of Organic Chemistry

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Well-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-06-20 , DOI: 10.1021/acs.joc.2c00167
Ankur Maji ₁ , Shivangi Gupta ₁ , Milan Maji ₁ , Sabuj Kundu ₁

Affiliation

Herein, we report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles, and pyridines from amino alcohols and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. We also detected two potential intermediates in the catalytic cycle using ESI-MS analysis. Based on these studies, a metal–ligand cooperative mechanism was proposed.

中文翻译：

定义明确的无膦锰 (II)-络合物催化合成喹啉、吡咯和吡啶

在此，我们报告了一种基于锰 (II) 配合物的简单、无膦且廉价的催化系统，用于从氨基醇和酮合成不同的重要 N-杂环化合物，如喹啉、吡咯和吡啶。进行了几个控制实验、动力学研究和 DFT 计算以支持合理的反应机制。我们还使用 ESI-MS 分析检测到催化循环中的两种潜在中间体。基于这些研究，提出了一种金属-配体协同机制。

更新日期：2022-06-20

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