To evaluate how spontaneous breathing trial (SBT) affects successful extubation and prognosis in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients under mechanical ventilation. AECOPD patients under invasive mechanical ventilation were recruited into the study and divided into the SBT and non-SBT groups. SBT patients received SBT for 60 min before extubation, while non-SBT patients that met weaning criteria were immediately extubated without SBT. A total of 64 patients were enrolled in analysis, including 32 in SBT group and 32 in non-SBT group. Patients in the two groups had similar baseline demographics and clinical characteristics (all parameters: p = > 0.05). Four (12.5%) patients in the SBT group and 5 (15.6%) in the non-SBT group were reintubated in 48 h of extubation (p = 0.821). During the 28-day follow-up after extubation, 3 patients died, 1 (3.1%) in the SBT group and 2 (6.3%) in the non-SBT group (p = 0.554). Our findings indicate that SBT did not affect extubation success, in-hospital mortality, and 28-day survival in AECOPD patients under mechanical ventilation.

中文翻译：

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自主呼吸试验对机械通气下慢性阻塞性肺疾病急性加重期患者拔管的影响

评估自主呼吸试验 (SBT) 如何影响机械通气下慢性阻塞性肺疾病 (AECOPD) 患者急性发作的成功拔管和预后。有创机械通气下的 AECOPD 患者被招募到研究中，并分为 SBT 组和非 SBT 组。SBT 患者在拔管前接受 SBT 60 分钟，而非 SBT 患者符合撤机标准立即拔管而不进行 SBT。共有64例患者入组分析，其中SBT组32例，非SBT组32例。两组患者的基线人口统计学和临床​​特征相似（所有参数：p = > 0.05）。SBT 组 4 名 (12.5%) 患者和非 SBT 组 5 名 (15.6%) 患者在拔管 48 小时后重新插管 (p = 0.821)。在拔管后的 28 天随访中，3 例患者死亡，其中 SBT 组 1 例（3.1%）和非 SBT 组 2 例（6.3%）（p = 0.554）。我们的研究结果表明，SBT 不影响机械通气下 AECOPD 患者的拔管成功率、住院死亡率和 28 天生存率。