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Anti-inflammatory abietanes diterpenes and triterpenoids isolated from Clinopodium polycephalum
Fitoterapia ( IF 3.4 ) Pub Date : 2022-06-18 , DOI: 10.1016/j.fitote.2022.105244 Yaxuan Liu 1 , Huijie Song 1 , Jixuan Xu 1 , Guangming Bi 1 , Dali Meng 1
更新日期：2022-06-22
Fitoterapia ( IF 3.4 ) Pub Date : 2022-06-18 , DOI: 10.1016/j.fitote.2022.105244 Yaxuan Liu 1 , Huijie Song 1 , Jixuan Xu 1 , Guangming Bi 1 , Dali Meng 1
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Two previously undescribed diterpenes (1 and 2), as well as one curious triterpenoid were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses, UV spectrum, and extensive 2D-homo and heteronuclear NMR data interpretations. Among them, 1 had an unusual skeletal characteristic produced by a rare methyl migration pathway. All monomer compounds exhibited inhibitory effects on NO production in LPS-induced RAW 264.7 cells without affecting cell viabilities, which were comparable to that of positive control.
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