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Cu-Doped Polypyrrole with Multi-Catalytic Activities for Sono-Enhanced Nanocatalytic Tumor Therapy
Small ( IF 13.0 ) Pub Date : 2022-06-19 , DOI: 10.1002/smll.202202964 Ting Chen 1 , Weiwei Zeng 1 , Yuanqi Liu 1 , Mian Yu 1 , Chenyi Huang 1 , Zhaoqing Shi 1 , Chuchu Lin 1 , Jia Tang 1 , Lin Mei 1, 2 , Meiying Wu 1
Small ( IF 13.0 ) Pub Date : 2022-06-19 , DOI: 10.1002/smll.202202964 Ting Chen 1 , Weiwei Zeng 1 , Yuanqi Liu 1 , Mian Yu 1 , Chenyi Huang 1 , Zhaoqing Shi 1 , Chuchu Lin 1 , Jia Tang 1 , Lin Mei 1, 2 , Meiying Wu 1
Affiliation
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Nanocatalytic medicine is a burgeoning disease treatment model with high specificity and biosafety in which the nanocatalyst is the core of driving catalytic reaction to generate therapeutic outcomes. However, the robust defense systems in the pathological region would counteract nanocatalyst-initiated therapeutics. Here, a Cu-doped polypyrrole is innovatively developed by a facile oxidative polymerization reaction, which exhibits intriguing multi-catalytic activities, including catalyzing H2O2 to generate O2 and ·OH, and consuming reduced glutathione by a Cu(II)-Cu(I) transition approach. By decorating with sonosensitizers and DSPE-PEG, the obtained CuPPy-TP plus US irradiation can induce severe oxidative damage to tumor cells by amplifying oxidative stress and simultaneously relieving antioxidant capacity in tumors based on the highly effective sonochemical and redox reactions. The notable tumor-specific biodegradability, remarkable cell apoptosis in vitro, and tumor suppression in vivo are demonstrated in this work, which not only present a promising biocompatible antitumor nanocatalyst but also broaden the perspective in oxidative stress-based antitumor therapy.
中文翻译：
具有多重催化活性的铜掺杂聚吡咯用于声增强纳米催化肿瘤治疗
纳米催化医学是一种新兴的具有高特异性和生物安全性的疾病治疗模式，其中纳米催化剂是驱动催化反应产生治疗结果的核心。然而，病理区域强大的防御系统会抵消纳米催化剂引发的治疗。在这里，通过简单的氧化聚合反应创新地开发了一种铜掺杂的聚吡咯，该反应表现出有趣的多催化活性，包括催化H 2 O 2生成O 2和· OH，以及通过Cu(II)-消耗还原型谷胱甘肽。 Cu(I) 过渡方法。通过声敏剂和DSPE-PEG修饰，所获得的CuPPy-TP加上US辐照可基于高效的声化学和氧化还原反应，通过放大氧化应激并同时缓解肿瘤的抗氧化能力，对肿瘤细胞造成严重的氧化损伤。这项工作证明了显着的肿瘤特异性生物降解性、显着的体外细胞凋亡和体内肿瘤抑制作用，不仅提供了一种有前途的生物相容性抗肿瘤纳米催化剂，而且拓宽了基于氧化应激的抗肿瘤治疗的前景。
更新日期：2022-06-19
中文翻译：
具有多重催化活性的铜掺杂聚吡咯用于声增强纳米催化肿瘤治疗
纳米催化医学是一种新兴的具有高特异性和生物安全性的疾病治疗模式，其中纳米催化剂是驱动催化反应产生治疗结果的核心。然而，病理区域强大的防御系统会抵消纳米催化剂引发的治疗。在这里，通过简单的氧化聚合反应创新地开发了一种铜掺杂的聚吡咯，该反应表现出有趣的多催化活性，包括催化H 2 O 2生成O 2和· OH，以及通过Cu(II)-消耗还原型谷胱甘肽。 Cu(I) 过渡方法。通过声敏剂和DSPE-PEG修饰，所获得的CuPPy-TP加上US辐照可基于高效的声化学和氧化还原反应，通过放大氧化应激并同时缓解肿瘤的抗氧化能力，对肿瘤细胞造成严重的氧化损伤。这项工作证明了显着的肿瘤特异性生物降解性、显着的体外细胞凋亡和体内肿瘤抑制作用，不仅提供了一种有前途的生物相容性抗肿瘤纳米催化剂，而且拓宽了基于氧化应激的抗肿瘤治疗的前景。
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