High-field asymmetric waveform ion mobility spectrometry (FAIMS) is a specific ion mobility device used to detect and characterize gas-phase ions under ambient conditions. This device separates ions based on differences in their mobilities, which are characterized by alpha dependence (α(E/N)). However, no effective theoretical model currently exists to describe the accuracy and optimize experimental parameters. Therefore, this paper describes a model of uncertainty to provide fast and effective guidance for optimally selecting experimental parameters and accurately evaluating the detection results of FAIMS. This model reveals how the deviations of α₂ and α₄ depend on the dispersion voltage (DV) and other parameters. Further, we evaluate three meaningful findings. The first is the relationship between α₂ and α₄. The second is the optimal sequence of DV, which does not generally utilize an arithmetic progression, but only contains two components (1 and 0.758 for α₂, and 1 and 0.749 for α₄), where the measurement times required for the optimal sequence of DV were approximately 50 % less than that needed for an arithmetic progression. Finally, we determine that the optimal values of the rectangular asymmetric waveform field ratio are 1/3 for α₂ and 0.377 for α₄. This analytical model and its inferences were verified extensively using a home-made tandem FAIMS device, which worked by selecting ions in the first stage and analyzing them in the second stage, thus eliminating the interference from noise signals and obtaining accurate results.

高场非对称波形离子迁移谱 (FAIMS) 是一种特定的离子迁移设备，用于在环境条件下检测和表征气相离子。该装置根据离子迁移率的差异分离离子，其特征在于 α 依赖性 ( α ( E / N ))。然而，目前还没有有效的理论模型来描述精度和优化实验参数。因此，本文描述了一个不确定性模型，为优化选择实验参数和准确评估FAIMS的检测结果提供快速有效的指导。该模型揭示了α ₂和α _{4的偏差如何}取决于色散电压 (DV) 和其他参数。此外，我们评估了三个有意义的发现。首先是α ₂和α ₄之间的关系。二是DV的最优序列，一般不使用等差数列，只包含两个分量（α _{2为1和0.758，} α ₄为1和0.749 ），其中最优序列所需的测量次数DV 比等差数列所需的值大约低 50%。最后，我们确定矩形非对称波形场比的最佳值为α _{2的 1/3 和}α ₄的 0.377. 使用自制的串联FAIMS装置对该分析模型及其推论进行了广泛验证，该装置通过在第一阶段选择离子并在第二阶段对其进行分析，从而消除了噪声信号的干扰并获得准确的结果。