Efficacious and sustained release of an anticancer drug mitoxantrone from new covalent organic frameworks using protein corona,Chemical Science

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Efficacious and sustained release of an anticancer drug mitoxantrone from new covalent organic frameworks using protein corona
Chemical Science ( IF 7.6 ) Pub Date : 2022-06-18 , DOI: 10.1039/d2sc00260d
Subhajit Bhunia _{1,

2} , Pranay Saha ₂ , Parikshit Moitra _{2,

3} , Matthew A Addicoat ₄ , Santanu Bhattacharya _{2,

5}

Affiliation

Solid porous and crystalline covalent organic frameworks (COFs) are characterized by their higher specific BET surface areas and functional pore walls, which allow the adsorption of various bioactive molecules inside the porous lattices. We have introduced a perylene-based COF, PER@PDA-COF-1, which acts as an effective porous volumetric reservoir for an anticancer drug, mitoxantrone (MXT). The drug-loaded COF (MXT–PER@PDA-COF-1) exhibited zero cellular release of MXT towards cancer cells, which can be attributed to the strong intercalation between the anthracene-dione motif of the drug and the perylene-based COF backbone. Here, we have introduced a strategy involving the serum-albumin-triggered intracellular release of mitoxantrone from MXT–PER@PDA-COF-1. The serum albumin acts as an exfoliating agent and as a colloidal stabilizer in PBS medium (pH = 7.4), rapidly forming a protein corona around the exfoliated COF crystallites and inducing the sustained release of MXT from the COF into tumorigenic cells.

中文翻译：

使用蛋白电晕从新的共价有机框架中有效且持续地释放抗癌药物米托蒽醌

固体多孔和结晶共价有机框架（COF）的特点是具有较高的比BET表面积和功能性孔壁，可以在多孔晶格内吸附各种生物活性分子。我们推出了一种基于苝的 COF，PER@PDA-COF-1，它可作为抗癌药物米托蒽醌 ( MXT ) 的有效多孔容积储库。载药 COF ( MXT –PER@PDA-COF-1) 对癌细胞的MXT细胞释放为零，这可归因于药物的蒽二酮基序与基于苝的 COF 主链之间的强烈嵌入。在这里，我们引入了一种涉及血清白蛋白触发MXT –PER@PDA-COF-1 米托蒽醌细胞内释放的策略。血清白蛋白在 PBS 介质（pH = 7.4）中充当剥落剂和胶体稳定剂，在剥落的 COF 微晶周围快速形成蛋白冠，并诱导MXT从 COF 持续释放到致瘤细胞中。

更新日期：2022-06-22

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