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Design, Synthesis, and Analytical Evaluation of Fsp3-Inspired Raman Probes for Cellular Imaging
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-06-17 , DOI: 10.1002/ejoc.202200393 Craig F. Steven 1 , Martin Lee 2 , Gary S. Nichol 1 , Paul R. J. Davey 3 , Elisabetta Chiarparin 3 , Valerie G. Brunton 2 , Alison Nicola Hulme 4
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-06-17 , DOI: 10.1002/ejoc.202200393 Craig F. Steven 1 , Martin Lee 2 , Gary S. Nichol 1 , Paul R. J. Davey 3 , Elisabetta Chiarparin 3 , Valerie G. Brunton 2 , Alison Nicola Hulme 4
Affiliation
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New tags have been developed for stimulated Raman scattering (SRS) cellular imaging with increased Fsp3 character over existing alternatives. These diyne-containing tags were synthesised by an efficient Pd-catalysed cross-coupling methodology and analysed by mass spectrometry (MS) association studies and X-ray crystallography before imaging. MS data showed a linear relationship between aggregation and cLogP whilst X-ray experiments suggested modifications had affected π-π stacking.
中文翻译：
用于细胞成像的受 Fsp3 启发的拉曼探针的设计、合成和分析评估
新标签已被开发用于受激拉曼散射 (SRS) 细胞成像，其 Fsp 3特性比现有替代品更高。这些含二炔的标签通过有效的 Pd 催化交叉偶联方法合成，并在成像前通过质谱 (MS) 关联研究和 X 射线晶体学进行分析。MS 数据显示聚集和 cLog P之间存在线性关系，而 X 射线实验表明修改影响了 π-π 堆积。
更新日期：2022-06-17
中文翻译：
用于细胞成像的受 Fsp3 启发的拉曼探针的设计、合成和分析评估
新标签已被开发用于受激拉曼散射 (SRS) 细胞成像，其 Fsp 3特性比现有替代品更高。这些含二炔的标签通过有效的 Pd 催化交叉偶联方法合成，并在成像前通过质谱 (MS) 关联研究和 X 射线晶体学进行分析。MS 数据显示聚集和 cLog P之间存在线性关系，而 X 射线实验表明修改影响了 π-π 堆积。
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