Advances in Translational 3D Printing for Cartilage, Bone, and Osteochondral Tissue Engineering,Small

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Advances in Translational 3D Printing for Cartilage, Bone, and Osteochondral Tissue Engineering
Small ( IF 13.0 ) Pub Date : 2022-06-17 , DOI: 10.1002/smll.202201869
Shenqiang Wang ₁ , Sheng Zhao ₁ , Jicheng Yu _{1,

2} , Zhen Gu _{1,

2,

3,

4,

5} , Yuqi Zhang _{1,

6}

Affiliation

The regeneration of 3D tissue constructs with clinically relevant sizes, structures, and hierarchical organizations for translational tissue engineering remains challenging. 3D printing, an additive manufacturing technique, has revolutionized the field of tissue engineering by fabricating biomimetic tissue constructs with precisely controlled composition, spatial distribution, and architecture that can replicate both biological and functional native tissues. Therefore, 3D printing is gaining increasing attention as a viable option to advance personalized therapy for various diseases by regenerating the desired tissues. This review outlines the recently developed 3D printing techniques for clinical translation and specifically summarizes the applications of these approaches for the regeneration of cartilage, bone, and osteochondral tissues. The current challenges and future perspectives of 3D printing technology are also discussed.

中文翻译：

用于软骨、骨骼和骨软骨组织工程的平移 3D 打印进展

用于转化组织工程的具有临床相关尺寸、结构和分级组织的 3D 组织结构的再生仍然具有挑战性。3D 打印是一种增材制造技术，通过制造具有精确控制的成分、空间分布和结构的仿生组织结构，可以复制生物和功能性天然组织，从而彻底改变了组织工程领域。因此，3D 打印作为一种可行的选择，通过再生所需组织来推进各种疾病的个性化治疗，正受到越来越多的关注。本综述概述了最近开发的用于临床翻译的 3D 打印技术，并特别总结了这些方法在软骨、骨骼和骨软骨组织再生中的应用。

更新日期：2022-06-17

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