Herb-Functionalized Chronic Wound Dressings for Enhancing Biological Functions: Multiple Flavonoids Coordination Driven Strategy,Advanced Functional Materials

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Herb-Functionalized Chronic Wound Dressings for Enhancing Biological Functions: Multiple Flavonoids Coordination Driven Strategy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2022-06-16 , DOI: 10.1002/adfm.202204291
Meng Sun _{1,

2} , Shiqiao Peng ₃ , Changli Zhao ₁ , Juexin Huang ₁ , Jingyi Xia ₁ , Dan Ye ₃ , Xiaoqiu Dou ₁ , Wanying Hou ₂ , Chuanliang Feng ₁

Affiliation

Developing a hydrogel-based multiple plant flavonoids dressing can synergistically assist chronic wound closure and enable superior solubility and optimal therapeutic efficacy of loading flavonoids. Herein, cooperativity among plant flavonoids to enhance their biological functions is built upon co-assemblies and chirality transfer. Co-assemblies of multi-flavonoids are fabricated through noncovalent interactions between flavonoids with the same skeleton and supramolecular hydrogelators. Chirality transfer from co-assemblies to poly(vinyl alcohol) and chitosan is enabled through chain−chain noncovalent interactions, which in turn improves mechanical strength and water absorbing capacity to adapt the changes of wound. Additionally, the optimal hydrogel shows the facilitated healing process due to the matching physicochemical properties and the cooperative therapeutic effects. This study may put forward new insights to design and build a new generation of multiple therapeutic effects of hydrogel dressing to accelerate chronic wound healing by adjusting the assembly process of multiple precursors in a sophisticated cooperative strategy.

中文翻译：

用于增强生物功能的草药功能化慢性伤口敷料：多种黄酮类化合物协调驱动策略

开发一种基于水凝胶的多种植物类黄酮敷料可以协同帮助慢性伤口闭合，并实现加载类黄酮的卓越溶解度和最佳治疗效果。在此，植物类黄酮之间的协同作用以增强其生物功能是建立在共组装和手性转移的基础上的。通过具有相同骨架的类黄酮与超分子水凝胶剂之间的非共价相互作用制备多类黄酮的共组装体。通过链-链非共价相互作用实现了从共组装体到聚（乙烯醇）和壳聚糖的手性转移，这反过来又提高了机械强度和吸水能力以适应伤口的变化。此外，由于匹配的物理化学性质和协同治疗效果，最佳水凝胶显示出促进的愈合过程。该研究可能为设计和构建新一代水凝胶敷料的多重治疗效果以通过在复杂的合作策略中调整多种前体的组装过程来加速慢性伤口愈合提出新的见解。

更新日期：2022-06-16

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