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Recyclable Luminescent Sensor for Detecting Creatinine Based on a Lanthanide–Organic Framework
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2022-06-17 , DOI: 10.1021/acs.inorgchem.2c00850 Li Luo 1 , Yao Xie 1 , Sheng-Li Hou 1 , Yue Ma 1 , Bin Zhao 1
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2022-06-17 , DOI: 10.1021/acs.inorgchem.2c00850 Li Luo 1 , Yao Xie 1 , Sheng-Li Hou 1 , Yue Ma 1 , Bin Zhao 1
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Creatinine is an important clinical marker for human health, but detecting it by a luminescent sensor based on metal–organic frameworks is rarely investigated. In this work, we synthesized a new lanthanide–organic framework {[Tb(L)(CH3COO)(H2O)]·0.5DMF}n (1) (H2L = 3,5-bis(4′-carboxy-phenyl)1,2,4-triazole) with good solvent and acid/alkaline stabilities. Experimental results indicate that 1 can be used in the detection of creatinine in an aqueous solution with a wide linear detection range from 3.27 to 371 μM, and the detection limit can reach 1.7 × 10–6 M based on the 3σ method, which is less than the pathogenic concentration in a real environment. In addition, this luminescent sensor can also monitor the concentration changes of creatinine in diluted serum solutions and can be recycled at least five times, suggesting that it has a potential application for clinical monitoring.
中文翻译：
基于镧系元素-有机框架的用于检测肌酐的可回收发光传感器
肌酐是人类健康的重要临床标志物，但很少研究通过基于金属-有机框架的发光传感器对其进行检测。在这项工作中，我们合成了一种新的镧系元素-有机骨架{[Tb(L)(CH 3 COO)(H 2 O)]·0.5DMF} n ( 1 ) (H 2 L = 3,5-bis(4′ -羧基-苯基）1,2,4-三唑）具有良好的溶剂和酸/碱稳定性。实验结果表明，1可用于水溶液中肌酐的检测，线性检测范围为3.27～371 μM，检测限可达1.7×10 –6M 基于 3σ 方法，小于真实环境中的病原浓度。此外，这种发光传感器还可以监测稀释血清溶液中肌酐的浓度变化，并且可以循环使用至少5次，这表明它在临床监测方面具有潜在的应用价值。
更新日期：2022-06-17
中文翻译：
基于镧系元素-有机框架的用于检测肌酐的可回收发光传感器
肌酐是人类健康的重要临床标志物，但很少研究通过基于金属-有机框架的发光传感器对其进行检测。在这项工作中，我们合成了一种新的镧系元素-有机骨架{[Tb(L)(CH 3 COO)(H 2 O)]·0.5DMF} n ( 1 ) (H 2 L = 3,5-bis(4′ -羧基-苯基）1,2,4-三唑）具有良好的溶剂和酸/碱稳定性。实验结果表明，1可用于水溶液中肌酐的检测，线性检测范围为3.27～371 μM，检测限可达1.7×10 –6M 基于 3σ 方法，小于真实环境中的病原浓度。此外，这种发光传感器还可以监测稀释血清溶液中肌酐的浓度变化，并且可以循环使用至少5次，这表明它在临床监测方面具有潜在的应用价值。
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