TiO2 Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing,Analytical Chemistry

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TiO2 Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-06-17 , DOI: 10.1021/acs.analchem.2c01383
Qianqian Zhao ₁ , Wenkai Zhu ₁ , Wenrong Cai ₁ , Junyao Li ₁ , Datong Wu ₁ , Yong Kong ₁

Affiliation

Chiral analysis is of significant importance for living organisms since chirality is the fundamental phenomenon in nature. In this work, a bifunctional electrochemiluminescent (ECL) platform is constructed for chiral discrimination and chiral sensing. 3-Mercaptopropionic acid-functionalized CdSe quantum dots (CdSe QDs) are combined with aminated TiO₂ nanotubes (NH₂-TiNTs) via amidation. The resultant CdSe QDs/TiNTs display significantly enhanced ECL signals due to the synergistic effect between CdSe QDs and TiNTs, which are then used for the chiral discrimination of the isomers of nine chiral amino acids (AAs) in the presence of d-AA oxidase (DAAO). DAAO can selectively catalyze the oxidation of d-AAs to generate H₂O₂, which acts as the coreaction reagent and triggers the ECL signals of CdSe QDs/TiNTs, and thus, the isomers of the nine chiral AAs can be effectively discriminated. In addition, the as-constructed ECL platform can also be used for the sensitive detection of d-AAs in the presence of DAAO with a wide linear range and a low limit of detection. These findings suggest that the CdSe QDs/TiNTs can work as a bifunctional ECL platform (chiral discrimination and chiral sensing), which might be an advanced ECL platform for biomedical applications.

中文翻译：

用 CdSe 量子点装饰的 TiO2 纳米管：用于手性识别和手性传感的双功能电化学发光平台

由于手性是自然界的基本现象，因此手性分析对生物体具有重要意义。在这项工作中，构建了一个用于手性识别和手性传感的双功能电化学发光 (ECL) 平台。3-巯基丙酸功能化 CdSe 量子点 (CdSe QD) 通过酰胺化与胺化 TiO ₂纳米管 (NH ₂ -TiNT) 结合。由于 CdSe QDs 和 TiNTs 之间的协同作用，所得 CdSe QDs/TiNTs 显示出显着增强的 ECL 信号，然后将其用于在d -AA 氧化酶存在下对九种手性氨基酸 (AAs) 的异构体进行手性区分。大奥）。DAAO可以选择性催化d -AAs氧化生成H ₂O ₂作为共反应试剂触发CdSe QDs/TiNTs的ECL信号，因此可以有效区分九种手性AA的异构体。此外，所构建的ECL平台还可用于DAAO存在下d -AAs的灵敏检测，线性范围宽，检测限低。这些发现表明，CdSe QDs/TiNTs 可以作为双功能 ECL 平台（手性辨别和手性传感），这可能是用于生物医学应用的先进 ECL 平台。

更新日期：2022-06-17

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