Abstract: Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and epithelial cells during inflammation. Herein, we summarize the latest knowledge on the functional expression of podoplanin in the immune system and review the contribution of podoplanin to several inflammatory diseases. Furthermore, we discuss podoplanin as a novel therapeutic target for various inflammatory diseases.

Keywords: podoplanin, immune system, inflammation


中文翻译：

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Podoplanin 在免疫系统和炎症中的作用

摘要： Podoplanin是一种小细胞表面粘蛋白样糖蛋白，参与多种生理和病理过程。Podoplanin 在免疫反应中发挥重要作用，并在炎症期间在成纤维细胞、巨噬细胞、T 辅助细胞和上皮细胞中上调。在此，我们总结了关于podoplanin在免疫系统中的功能表达的最新知识，并回顾了podoplanin对几种炎症性疾病的贡献。此外，我们讨论了podoplanin作为各种炎症性疾病的新治疗靶点。

关键词： podoplanin，免疫系统，炎症