Abstract

A novel drug-carrier for paclitaxel entrapment entitled CMC/MATPP-PTX(CTP) was developed starting from the synthesis of MATPP that was grafted to CMC when EDC/NHS was served as coupling agent. Fourier Infrared Spectrometer (FT-IR) and ¹H Nuclear Magnetic Resonance (¹H NMR) characterized their constituents and structures information. Laser particle size analyzer (LPSA) and Scanning electron microscope (SEM) measured their size distribution and observed their morphology. Results showed substitution rate of CMC is up to 0.229 when the CMC: MATPP (mole ratio) is 1:0.016. CTP represents different microscale in distinct ratio of H₂O/Ethanol or H₂O/Acetone aqueous solution. SEM revealed the CTP possess a mean 500 ± 40 nm sizes. PTX loading and encapsulation rates are 14.6% and 8.9% when the ratio of CMC/MATPP:PTX (mole ratio) is 1:2, respectively. The cumulative release of paclitaxel can reach up to 59.75% within 5 h.

摘要

以EDC/NHS为偶联剂，合成MATPP接枝到CMC上，开发了一种新型的紫杉醇包埋药物载体CMC/MATPP-PTX(CTP)。傅立叶红外光谱仪 (FT-IR) 和¹ H 核磁共振 ( ¹ H NMR) 表征了它们的成分和结构信息。激光粒度分析仪（LPSA）和扫描电子显微镜（SEM）测量了它们的粒度分布并观察了它们的形貌。结果表明，当CMC：MATPP（摩尔比）为1：0.016时，CMC的取代率高达0.229。_{CTP以不同的H 2} O/乙醇或H ₂的比例代表不同的微观尺度O/丙酮水溶液。SEM 显示 CTP 的平均尺寸为 500 ± 40 nm。当 CMC/MATPP:PTX (摩尔比) 为 1:2 时, PTX 负载率和包封率分别为 14.6% 和 8.9%。紫杉醇的累积释放在5小时内可达59.75%。