Force-Coded Strategy for the Simultaneous Detection of Multiple Tumor-Related Proteins,Analytical Chemistry

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Force-Coded Strategy for the Simultaneous Detection of Multiple Tumor-Related Proteins
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-06-17 , DOI: 10.1021/acs.analchem.2c01014
Mengxue Sun _{1,

2} , Pan Lu _{1,

2} , Chanchan Yu _{1,

2} , Feng Feng _{1,

2} , Qilong Li _{1,

2} , Jinxiu Zhan _{1,

2} , Min Xu _{1,

2} , Yajing Liu _{1,

2} , Li Yao _{1,

2}

Affiliation

Multiplexed simultaneous detection of various cancer markers is required for accurate diagnosis and treatment of early cancer. In this work, we present a force-coded strategy for the simultaneous detection of tumor-related proteins with tunable dynamic range via magnetic sensing. The multiplexing capability of this method is achieved by designing DNA devices that can recognize different biomarkers and code them with different binding forces measured by the force-induced remnant magnetization spectroscopy, which is not influenced by the color of the light and the solution. Moreover, the force-coded assay with high sensitivity and adjustable detection range is robust, which could be used for practical biological applications such as magnetic sensing, handheld miniaturized systems, and potential in vivo diagnosis.

中文翻译：

同时检测多种肿瘤相关蛋白的强制编码策略

早期癌症的准确诊断和治疗需要多种癌症标志物的多路同时检测。在这项工作中，我们提出了一种力编码策略，用于通过磁感应同时检测具有可调动态范围的肿瘤相关蛋白。这种方法的多路复用能力是通过设计可以识别不同生物标志物的 DNA 设备来实现的，该设备可以用力诱导的剩余磁化光谱测量的不同结合力对其进行编码，不受光和溶液颜色的影响。此外，具有高灵敏度和可调节检测范围的力编码检测方法稳健，可用于实际生物应用，如磁传感、手持小型化系统和潜在的体内诊断。

更新日期：2022-06-17

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