D-π-A Dual-Mode Probe Design for the Detection of nM-Level Typical Oxidants,Analytical Chemistry

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D-π-A Dual-Mode Probe Design for the Detection of nM-Level Typical Oxidants
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-06-17 , DOI: 10.1021/acs.analchem.2c01894
Xinyi Yang ₁ , Zhenzhen Cai ₂ , Dezhong Li ₁ , Da Lei ₂ , Yushu Li ₂ , Guangfa Wang ₂ , Jun Zhang ₁ , Xincun Dou _{2,

3}

Affiliation

Although a set of functional molecules with the D-π-A structure has been explored as optical probes for the detection of target analytes, it remains a great challenge to elaborately design a single probe for distinguishing different analytes by their intrinsic oxidation or reduction capabilities and thus to generate distinct optical responses. Here, a unique TCF-based probe (DMA-CN) containing two unsaturated double bonds in the π-conjugation bridge and TCF with different reaction activities that could be cut off by KMnO₄ and NaClO in varying degrees was developed, causing remarkably distinguishable responses for both fluorescence and colorimetric channels to discriminate KMnO₄ and NaClO from each other. The fluorescence and colorimetric limits of detection (LODs) of the proposed DMA-CN toward KMnO₄ were calculated as 60 and 91 nM, respectively, while those for NaClO were 13.3 and 214 nM, and all the optical signal change can be observed within 1 s with good specificity. Based on the proposed probe design strategy, a well-fabricated test strip was proven to be promising for the rapid, in-field detection and risk management. We expect that the present probe design methodology would provide a powerful strategy for efficient probe exploration, especially for discriminating the substances with similar oxidizing properties.

中文翻译：

用于检测 nM 级典型氧化剂的 D-π-A 双模式探头设计

尽管已经探索了一组具有 D-π-A 结构的功能分子作为检测目标分析物的光学探针，但精心设计一个单一的探针以通过其固有的氧化或还原能力来区分不同的分析物仍然是一个巨大的挑战。从而产生不同的光学响应。在这里，开发了一种独特的基于 TCF 的探针 (DMA-CN)，在 π 共轭桥中包含两个不饱和双键和具有不同反应活性的 TCF，可被 KMnO ₄和 NaClO 不同程度地切断，产生显着可区分的响应用于区分 KMnO _{4的荧光和比色通道}和 NaClO 相互分离。_{所提出的 DMA-CN 对 KMnO 4}的荧光和比色检测限 (LOD)分别计算为 60 和 91 nM，而对 NaClO 的荧光和比色检测限 (LOD) 分别为 13.3 和 214 nM，并且可以在 1 内观察到所有的光信号变化具有良好的特异性。基于所提出的探针设计策略，一个制作精良的测试条被证明有希望用于快速、现场检测和风险管理。我们期望目前的探针设计方法将为有效的探针探索提供强有力的策略，特别是用于区分具有相似氧化特性的物质。

更新日期：2022-06-17

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